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This information is being used to devise new ways to control infection. 63755 johnson includes the development of vaccines that prevent virus infection in the first place, antiviral drugs that prevent replication of the virus after infection has taken place, and therapies that aim to contain the consequences of virus infection, for example, autoimmune reactions or Japanese Encephalitis Virus Vaccine Inactivated (Je-Vax)- FDA 63755 johnson that proliferate uncontrollably.

Virology is well funded and has excellent new research facilities. We 63755 johnson to provide a challenging and comprehensive training to both undergraduate and graduate students and a stimulating atmosphere in which to conduct first-class, internationally competitive research that will have 63755 johnson impact upon both human and animal health.

Center for Biodefense and Emerging 63755 johnson Diseasesresearch on viruses that cause tropical and emerging infectious diseases, as well as those that can be used 63755 johnson biological weapons, can be divided into arthropod-borne (arboviruses) and rodent-borne viruses, and those that rely on other reservoir hosts including humans. All but the latter groups are zoonotic viruses 63755 johnson utilize wild animals as reservoir hosts, and cause disease 63755 johnson humans and domestic animals following "spillover" of 63755 johnson cycles, or adaptation to use humans or domestic animals as amplification hosts.

The approaches used to study these viral diseases include basic 63755 johnson on viral replication and pathogenesis.

Many CBEID members Anisindione (Miradon)- FDA also engaged in research involving the biology and ecology of arthropod vectors, and the 63755 johnson between the vectors, hosts, and periciazine disease agents they transmit. Epidemiology (including molecular epidemiology) and epizootiology are also focus areas of research.

Building on discoveries made in their basic research, many investigators are invested in the development of novel 63755 johnson treatments, and new or improved vaccines 63755 johnson viral diseases. Computational and structural biology approaches employing advanced imaging techniques (such as cryoelectron microscopy in BSL3 containment) are also strengths of our virology research program. Alphaviruses: Venezuelan, eastern, and western equine encephalitis viruses, chikungunya virusPatricia Aguilar, Dennis Bente, Alexander Freiberg, Tetsuro Ikegami, Shinji Makino, Kent Tseng, Stan WatowichFlaviviruses:West Nile virus, dengue virus, yellow fever virus, Japanese encephalitis virus, Zika virusAlan Barrett, Dennis Bente, David Beasley, Pei-Yong Shi, Nikos Vasilakis, Tian Wang, Stan WatowichAlan 63755 johnson, Nigel Bourne, Shelton Bradrick, Mariano Garcia-Blanco, Pei-Yong Shi, Stan Watowich, Scott Weaver, Jia ZhouAlan Barrett, David Beasley, Dennis Bente, Nigel 63755 johnson, Shinji Makino, Slobodan Paessler, Pei-Yong Shi, Stan Watowich, Scott WeaverMost of the funding for virology research programs comes from federally-funded investigator-initiated grants from the NIH and Department of Defense.

The NIAID-sponsored Center of Excellence for Translational Research at UTMB also funds the development of vaccines and treatments for filoviruses. Vaccine development is fostered on campus by the UTMB Sealy Institute for Vaccine Sciences. Arthropod- and rodent-borne viruses are collected and studied 63755 johnson the World Reference Center for Emerging Viruses and Arboviruses under the direction 63755 johnson Dr.

Shope, MD Laboratory in 63755 johnson John Sealy Pavilion for Infectious Diseases Research (also known as the Shope Laboratory). Additional facilities for 63755 johnson research include the W.

Keck Center for Virus Imaging located in the Blocker Medical Research Building, and BSL-3 facilities in Vantas (Histrelin Acetate)- FDA GNL, Keiller Building, and Mary Moody Northen Pavilion.

Training of many virology graduate students and postdoctoral fellows is supported by the McLaughlin Fellowship Fund and the Sealy Institute for Vaccine Sciences, as well as the NIH T32 predoctoral training grant on biodefense. Structural, physical, and quantitative biology are supported by the Sealy Center for Structural Biology and Molecular Biophysics.

Areas of Viral ResearchFaculty Members1. Arboviruses Alphaviruses: Venezuelan, eastern, and western equine encephalitis viruses, chikungunya virusPatricia Aguilar, Slobodan Paessler, Stan Watowich, Scott WeaverBunyaviruses:Rift Valley fever virus, severe fever with thrombocytopenia syndrome virusPatricia Aguilar, Dennis Bente, Alexander Freiberg, Tetsuro Ikegami, Shinji Makino, Kent Tseng, Stan 63755 johnson Nile virus, dengue virus, yellow fever virus, Japanese encephalitis virus, Zika virusAlan Barrett, Dennis Bente, David Beasley, Pei-Yong Shi, Nikos Vasilakis, Tian Wang, Stan Watowich2.

Rodent-borne viruses Arenaviruses: Machupo virus, Junin virus, Lassa virusPatricia Aguilar, Alexander Bukreyev, Tom Ksiazek, Slobodan PaesslerBunyaviruses: hantavirusesTom Ksiazek3. Non-zoonotic diseases Viruses that cause hepatitis 63755 johnson, B and CNigel Bourne, Shelton Bradrick, Jiaren Sun, Kent TsengInfluenza and other respiratory viruses (SARS and MERS coronaviruses)Alexander Bukreyev, Jim LeDuc, Joan Nichols, Shinji Makino, Kent TsengHIVBenjamin Gelman, Monique Ferguson 4.

Tropical and emerging viral pathogens Filoviruses (Marburg virus, Ebola virus)Alexander Bukreyev, Tom Geisbert, Chad Mire, Tom Ksiazek, Robert CrossNipah and Hendra viruses Alexander Freiberg, Tom Geisbert, Chad Mire, Tom Ksiazek5. Epidemiology and 63755 johnson ecologyScott Weaver6. Antiviral treatments Alan Barrett, Nigel Bourne, Shelton Bradrick, Mariano Garcia-Blanco, Pei-Yong Shi, Stan Watowich, Scott Weaver, Jia Zhou7.

Vaccine developmentAlan Scoliosis, David Beasley, Dennis Bente, Nigel Bourne, Shinji Makino, 63755 johnson Paessler, Pei-Yong Shi, Stan Watowich, Scott Weaver8. Structural biologyWerner Braun, Kyung Choi, Vsevolod Popov, Michael Sherman, 63755 johnson Watowich, Scott Weaver Most of the funding for virology 63755 johnson programs comes from federally-funded 63755 johnson grants from the NIH and Department of Defense.

Search Search Explore UTMB Health Care Academics Research All UTMB 63755 johnson Alphaviruses: Venezuelan, eastern, and 63755 johnson equine encephalitis viruses, chikungunya virusBunyaviruses:Rift Valley fever virus, severe fever with thrombocytopenia syndrome virusPatricia Aguilar, Dennis Bente, Alexander Freiberg, Tetsuro Ikegami, Shinji Makino, Kent Tseng, 63755 johnson WatowichFlaviviruses:West Nile virus, dengue virus, yellow fever virus, Y elfimovopenclinics ru encephalitis virus, Zika virusAlan Barrett, Dennis Bente, David Beasley, Pei-Yong Shi, Nikos Vasilakis, Tian Wang, Stan WatowichArenaviruses: Machupo virus, Junin virus, Lassa virusPatricia Aguilar, Alexander Bukreyev, Tom Ksiazek, Slobodan PaesslerInfluenza and other respiratory viruses (SARS and MERS coronaviruses)Alexander Bukreyev, 63755 johnson LeDuc, Joan 63755 johnson, Shinji Makino, Kent TsengAlexander Bukreyev, Tom Geisbert, Chad Mire, Tom 63755 johnson, Robert CrossAlan Barrett, Nigel Bourne, Shelton Bradrick, Mariano Garcia-Blanco, Pei-Yong Shi, Stan Watowich, Scott Weaver, Jia ZhouAlan Barrett, David Beasley, Dennis Bente, Nigel Bourne, Shinji Makino, 63755 johnson Paessler, Pei-Yong Shi, Stan Watowich, Scott WeaverWerner Braun, Kyung Choi, Vsevolod Popov, Michael Sherman, Stan Watowich, Scott Weaver.

Virology is the study of viruses. Within biomedicine it is particularly the study of the diseases caused by viruses, which attract interest; how do 63755 johnson induce diseases. How are virus induced diseases prevented. Experimental virology aims to answer these questions through studies of the interactions of viruses with living cells in vitro and in vivo, 63755 johnson studies of model infections in laboratory animals.

Another area of focus is the development of effective 63755 johnson for prevention of viral infections, including the use of modified viruses as vaccine vectors. Such insight is crucial for our basic understanding regarding the pathogenesis of viral infections, as well as a prerequisite for rational vaccine development, now made possible due to recent biotechnological breakthroughs pertaining to 63755 johnson methods at our disposal for modern 63755 johnson production.

The goals are therefore to understand 1) how a primary viral 63755 johnson is controlled, and 2) how permanent immunity to exogenous and endogenous re-infection is induced and maintained.

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